
A physician with decades of experience as a geriatric psychiatrist, Dr. Robert Kohn is a temporary advisor for the Pan American Health Organization/World Health Organization. Dr. Robert Kohn also serves as a professor of psychiatry in a local medical school in Providence, Rhode Island. In his solo practice clinic in Providence, Robert Kohn, MD, treats older adults with intellectual and developmental disorders, such as Alzheimer’s disease and other forms of dementia.
A team of scientists has found that sleep deprivation may cause impairment in the brain, and lack of sleep over long periods may be linked to an increased risk of Alzheimer’s disease. The study was published in the American Chemical Society’s Journal of Proteome Research.
The researchers used mice to discover that sleep deprivation can cause neurologic damage to the hippocampus, the part of the brain primarily involved in learning and memory. During the study, the mice were evaluated based on how well they navigated through a maze and how they recognized new objects in the maze after being deprived of sleep for two days. Then, proteins were extracted from the mice’s hippocampi and noted how the abundance of such proteins had changed. They also compared the mice’s performance with other animals not involved in the study.
The researchers found that the pleiotrophin (PTN) of the mice that lacked sleep declined, which may eventually lead to the death of the hippocampus. PTN is a protein-coding gene associated with growth factors. Compared with human genetics studies, PTN is implicated in neurodegenerative diseases such as Alzheimer’s.








